@article{86401,
  keywords = {Animals, signal transduction, Mutation, Transcription Factors, Trans-Activators, Membrane Proteins, Recombinant Fusion Proteins, Receptors, Cell Surface, Carrier Proteins, Female, Gene Expression Regulation, Developmental, Embryo, Nonmammalian, Drosophila melanogaster, Active Transport, Cell Nucleus, Adaptor Proteins, Signal Transducing, Drosophila Proteins, Proto-Oncogene Proteins, Glycogen Synthase Kinase 3, Armadillo Domain Proteins, Frizzled Receptors, Glycogen Synthase Kinase 3 beta, LDL-Receptor Related Proteins, Low Density Lipoprotein Receptor-Related Protein-5, Receptors, G-Protein-Coupled, Receptors, LDL, Wnt1 Protein},
  author = {Nicholas Tolwinski and Marcel Wehrli and Anna Rives and Naz Erdeniz and Stephen DiNardo and Eric Wieschaus},
  title = {Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity.},
  abstract = { Activation of the Wnt signaling cascade provides key signals during development and in disease. Here we provide evidence, by designing a Wnt receptor with ligand-independent signaling activity, that physical proximity of Arrow (LRP) to the Wnt receptor Frizzled-2 triggers the intracellular signaling cascade. We have uncovered a branch of the Wnt pathway in which Armadillo activity is regulated concomitantly with the levels of Axin protein. The intracellular pathway bypasses Gsk3beta/Zw3, the kinase normally required for controlling beta-catenin/Armadillo levels, suggesting that modulated degradation of Armadillo is not required for Wnt signaling. We propose that Arrow (LRP) recruits Axin to the membrane, and that this interaction leads to Axin degradation. As a consequence, Armadillo is no longer bound by Axin, resulting in nuclear signaling by Armadillo. },
  year = {2003},
  journal = {Dev Cell},
  volume = {4},
  pages = {407-18},
  month = {03/2003},
  issn = {1534-5807},
  language = {eng},
}